论文部分内容阅读
目的比较放射治疗与89Sr核素治疗对椎骨转移癌疼痛的临床疗效。方法回顾分析我院2005年1月至2010年5月期间治疗的椎骨转移癌疼痛患者143例,其中放疗组115例,根据单次剂量不同分为常规分割、中分割、低分割3组,89Sr核素治疗组28例。对放疗组之间、放疗组与89Sr治疗组之间的疼痛缓解有效率、起效时间进行比较。结果常规分割、中分割、低分割3组疼痛缓解有效率分别为90.63%(29/32)、84.21%(32/38)、80.00%(36/45),放疗总体疼痛缓解有效率84.35%(97/115),89Sr核素治疗疼痛缓解有效率78.57%(22/28)。不同放疗分割组间、放疗组与89Sr核素治疗组间疼痛缓解有效率无统计学差异(P>0.05)。常规分割、中分割、低分割组和89Sr治疗组缓解疼痛的起效时间分别为(14.21±2.51)、(7.78±2.96)、(2.83±1.56)、(9.27±2.88)d,4组间的差异具有统计学意义(H=90.152,P=0.000)。结论放射治疗与89Sr核素治疗对缓解椎体的骨转移性疼痛疗效相当,低分割放疗疼痛缓解的起效时间最短,常规分割起效时间最长。
Objective To compare the clinical effects of radiotherapy and 89Sr nuclide on the pain of vertebral metastatic carcinoma. Methods A total of 143 patients with vertebral metastatic cancer who were treated in our hospital from January 2005 to May 2010 were retrospectively analyzed. Among them, 115 patients in the radiotherapy group were divided into three groups according to the single dose: conventional, middle and low, 89Sr Nuclide treatment group of 28 cases. Between the radiotherapy group, radiotherapy group and 89Sr treatment group pain relief efficiency, onset time were compared. Results The effective rates of pain relief were 90.63% (29/32), 84.21% (32/38) and 80.00% (36/45) in the conventional, middle and low-resolution groups, respectively, and the overall effective rate of pain relief was 84.35% 97/115), 89Sr nuclide treatment of pain relief effective rate of 78.57% (22/28). There was no significant difference in the effective rate of pain relief between radiotherapy group and 89Sr nuclide group in different radiotherapy group (P> 0.05). The onset time of pain relief in routine, middle, low and 89Sr groups were (14.21 ± 2.51), (7.78 ± 2.96), (2.83 ± 1.56) and (9.27 ± 2.88) d, respectively The difference was statistically significant (H = 90.152, P = 0.000). Conclusions Radiation therapy and 89Sr radionuclide are effective in relieving bone metastatic pain of vertebral body. The onset time of pain relief in low-cut radiotherapy is the shortest, and the onset time of routine segmentation is the longest.