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目的:评价国产吉西他滨(泽菲)联合顺铂二线治疗晚期乳腺癌的疗效和不良反应。方法:34例晚期乳腺癌患者采用国产吉西他滨1000mg/m2,静脉滴注30min,第1、8天;顺铂25mg/m2,静脉滴注,第1～3天。21d为一个周期,至少完成两周期后评价疗效。结果:完全缓解2例(5.88%),部分缓解16例(47.06%),总有效率为52.94%。中位疾病进展时间为6.5月,中位生存期为11.4月;主要不良反应为骨髓抑制和胃肠道反应,所有不良反应在停药后或对症处理后均可恢复正常。结论:国产吉西他滨联合顺铂二线治疗晚期乳腺癌疗效较好,毒副反应可耐受,值得进一步研究。
Objective: To evaluate the efficacy and side effects of domestic gemcitabine (Zephyphy) plus cisplatin in the treatment of advanced breast cancer. Methods: 34 cases of advanced breast cancer patients with domestic gemcitabine 1000mg / m2, intravenous infusion 30min, first and eighth days; cisplatin 25mg / m2, intravenous drip, the 1st to 3 days. 21d for a cycle, at least after the completion of two cycles to evaluate the efficacy. Results: Complete remission in 2 cases (5.88%), partial remission in 16 cases (47.06%), the total effective rate was 52.94%. The median time to progression was 6.5 months, with a median survival of 11.4 months. The major adverse reactions were myelosuppression and gastrointestinal reactions, and all adverse reactions returned to normal after withdrawal or symptomatic treatment. Conclusion: The domestic gemcitabine combined with cisplatin second-line treatment of advanced breast cancer better efficacy, toxicity can be tolerated, worthy of further study.