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蒽环类抗菌素一般都具抗肿瘤活性。作者拟通过微生物方法,将该类抗菌素转化为新的抗肿瘤药物。研究发现,从污水中分离到的三株菌株 Aero-monas hydrophila.大肠杆菌和 Citrobacter freundii对该类抗菌素能引起苄氢解作用(Benzylichydrogenolysis).
Anthracyclines are generally anti-tumor activity. The authors intend to adopt microbial methods to convert such antibiotics into new antitumor drugs. The study found that three strains isolated from sewage Aero-monas hydrophila. Escherichia coli and Citrobacter freundii can cause benzylichydrogenolysis of this class of antibiotics (Benzylichydrogenolysis).