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目的 探讨慢性鼻窦炎患者血清中IgG4含量的临床意义。 方法 采用双抗体夹心ELISA法检测 79例慢性鼻窦炎患者、4 0例健康成人血清免疫球蛋白G4 (IgG4 )水平 ,同时对患者组和对照组作鼻分泌物嗜酸性粒细胞瑞氏染色计数和吸入物变应原皮肤试验。结果 慢性鼻窦炎患者血清IgG4水平为对照组的2 .0 9倍 ,差异经统计学处理有显著性意义(P <0 .0 1,t =5.74 5)。患者组鼻分泌物嗜酸性粒细胞阳性率为 4 4 .3% ,吸入物变应原皮肤试验阳性率为 4 9.4 % ,明显高于对照组。结论 慢性鼻窦炎反复发作往往有变应性因素参与。慢性鼻窦炎的发病是在一般炎症的基础上引起变态反应 ,而变态反应的发生又加重了炎症
Objective To investigate the clinical significance of serum IgG4 in patients with chronic sinusitis. Methods Serum immunoglobulin G4 (IgG4) levels were measured in 79 patients with chronic sinusitis and 40 healthy adults by double antibody sandwich ELISA. Nasopharyngeal eosinophil Wright staining was performed on patients and controls Inhalation allergen skin test. Results Serum IgG4 level in patients with chronic sinusitis was 2.9 times higher than that in the control group. The difference was statistically significant (P <0.01, t = 5.74 5). The positive rate of nasal discharge eosinophil in patients was 44.3%, and the positive rate of allergen skin test in inhalation was 44.4%, which was significantly higher than that of the control group. Conclusion Chronic sinusitis recurrent often have allergic factors involved. The incidence of chronic sinusitis is caused by the general inflammation on the basis of allergies, and the occurrence of allergies aggravate inflammation