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赛维健(注射用雷替曲塞)属叶酸结构类似物抗叶酸制剂,通过一系列途径进入细胞内作用于胸苷酸合成酶(TS),在细胞内代谢产生的多聚谷氨酸类化合物是比雷替曲塞更强的TS酶抑制剂,直接特异性的作用于叶酸结合部位,该化合物半衰期长达198小时,在细胞内长时间发挥抗肿瘤作用。雷替曲塞为非氟尿嘧啶类药物,与5-FU虽同属于TS酶抑制剂,但作用机制不同,不会导致相关
Sevren (injection of raltitrexed) is a folic acid structural analogue of anti-folic acid preparations, through a series of channels into the cell acting on the thymidylate synthase (TS), in the cell metabolism of polyglutamic acid The compound is a stronger TS enzyme inhibitor than raltitrexed and acts directly on the folic acid binding site. The compound has a half-life of up to 198 hours and exerts an antitumor effect in cells for a long time. Raltitrexed is a non-fluorouracil drug, and although 5-FU is a TS enzyme inhibitor, its mechanism of action does not lead to a correlation