论文部分内容阅读
目的 探讨增殖细胞核抗原 (PCNA )和Ki-6 7核抗原在脑膜瘤中的表达及其与肿瘤良、恶性及复发的关系。方法 采用LSAB法检测 80例脑膜瘤组织中PCNA和Ki-6 7的表达。结果 恶性脑膜瘤PCNA标记指数 (PCNALI)和Ki -6 7标记指数 (Ki -6 7LI)明显高于良性脑膜瘤 (P <0 .0 1)和非典型性脑膜瘤 (P <0 .0 5 ) ,复发脑膜瘤PCNALI显著高于未复发脑膜瘤 (P<0 .0 1) ,复发脑膜瘤Ki -6 7LI也显著高于未复发脑膜瘤 (P <0 .0 1)。Ki -6 7表达与PCNA表达呈正相关。结论 脑膜瘤细胞标记指数可作为判断脑膜瘤良、恶性的客观指标之一 ,标记指数对预测脑膜瘤的复发有一定意义。
Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) and Ki-67 nuclear antigen in meningioma and its relationship with benign and malignant tumor and recurrence. Methods LSAB method was used to detect the expression of PCNA and Ki-67 in 80 cases of meningiomas. Results The PCNA labeling index and Ki-67 labeling index (Ki -6 7LI) of malignant meningioma were significantly higher than those of benign meningiomas (P <0.01) and those of atypical meningiomas (P <0.05) ), And PCNALI in recurrent meningioma was significantly higher than that in non-recurrent meningioma (P <0.01). The Ki-67LI in recurrent meningioma was also significantly higher than that in non-recurrent meningioma (P <0.01). Ki-67 expression was positively correlated with PCNA expression. Conclusion The meningioma cell marker index can be used as one of the objective indicators to judge the benign and malignant meningiomas. The labeling index is of certain significance in predicting the recurrence of meningioma.