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观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人,并在1987-2012年间随诊心
Observational studies have identified the association between body mass index (BMI) and atrial fibrillation. However, inferring causal relationships from observational studies is influenced by confounding factors, inverse causal relationships and biases. The primary purpose of this study was to assess the causal relationship between BMI and atrial fibrillation using genetic predictors of BMI. METHODS: A total of 51 646 European descent individuals without atrial fibrillation were included in the cohort of seven prospective cohorts conducted in the United States, Iceland and the Netherlands during the period 1987-2002 and followed up between 1987 and 2012