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目的探讨中国江苏省宜兴地区汉族人群中Wnt-1诱导分泌蛋白2(WISP2)基因rs2281862位点C>T多态性与胃癌预后的关系。方法应用TaqMan探针的RT-PCR法检测952例胃癌患者的基因型,分析不同基因型与胃癌预后的关系。结果与WISP2基因rs2281862位点CC基因型相比,合并突变基因型TC和TT与胃癌的预后无显著相关性(P>0.05)。Lauren分型与胃癌患者的预后相关:与合并基因型CC和TC相比,在肠型胃癌患者中,TT型患者的预后危险性下降(P<0.05),而在弥漫型胃癌患者中,TT型患者的预后危险性增加(P<0.05)。结论中国江苏省宜兴地区汉族人群WISP2基因rs2281862位点与胃癌预后无关;TT基因型是肠型胃癌患者的保护性因素,但也是弥漫型胃癌患者的危险性因素。
Objective To investigate the relationship between Wnt-1 induced secretory protein 2 (WISP2) gene rs2281862 C> T polymorphism and gastric cancer prognosis in Han nationality in Yixing, Jiangsu Province, China. Methods The genotypes of 952 gastric cancer patients were detected by RT-PCR with TaqMan probe and the relationship between different genotypes and the prognosis of gastric cancer was analyzed. Results Compared with the CC genotype of rs2281862 in WISP2 gene, the TC and TT genotypes were not significantly correlated with the prognosis of gastric cancer (P> 0.05). Lauren’s classification is associated with the prognosis of patients with gastric cancer: Compared with CC and TC genotypes, TT patients have a lower risk of prognosis (P <0.05) in patients with gastrointestinal cancer, whereas in patients with diffuse gastric cancer, TT Type patients increased the risk of prognosis (P <0.05). Conclusion The rs2281862 locus of WISP2 gene in Han nationality in Yixing, Jiangsu Province, China is unrelated to the prognosis of gastric cancer. TT genotype is a protective factor in patients with intestinal-type gastric cancer, but it is also a risk factor for patients with diffuse gastric cancer.