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Survivin是凋亡抑制蛋白(inhibitor ofapoptosis,IAP)家族的新成员[1],与其他成员相比较,其结构和分布特殊,因而引起广泛的兴趣和研究。它具有抑制细胞凋亡、促进细胞转化并且参与细胞的有丝分裂、血管的生成和肿瘤细胞耐药性的产生等作用。本文就survivin及其在乳腺癌中的研究
Survivin is a new member of the inhibitor ofapoptosis (IAP) family [1]. Its structure and distribution are special compared with other members, which has attracted extensive interest and research. It has the function of inhibiting apoptosis, promoting cell transformation and participating in cell mitosis, blood vessel formation and tumor cell drug resistance. This article reviews survivin and its role in breast cancer