目的　探讨异丙酚对颅脑损伤患者开颅手术期间血浆内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）含量的影响。方法　急性颅脑损伤（ＡＣＩ）患者４０ 例，随机分为观察组（异丙酚组，ｎ＝ ２０，Ａ组）和对照组（γ羟基丁酸钠组，ｎ＝ ２０，Ｂ组）。以放射免疫分析方法测定４０ 例ＡＣＩ患者麻醉前后血浆ＥＴ、ＣＧＲＰ含量，并以４０例健康献血者为术前对照。结果　ＡＣＩ患者术前ＥＴ及ＥＴ／ＣＧＲＰ明显高于正常对照组（Ｐ＜ ００１）。麻醉后２ 小时，Ａ组ＥＴ较麻醉前显著性降低（Ｐ＜ ００１）而Ｂ组ＥＴ较麻醉前持续显著性升高（Ｐ＜ ００１）；麻醉后４ 小时，Ａ 组ＥＴ，ＥＴ／ＣＧＲＰ较麻醉前更进一步降低（Ｐ＜ ００１），而ＣＧＲＰ较麻醉前有显著性升高且明显高于正常对照组。而Ｂ组ＥＴ较麻醉前仍有显著性升高（Ｐ＜００１），组间比较有显著性差异（Ｐ＜ ００１）。结论　血浆ＥＴ含量变化与颅脑损伤后脑组织继发性损害病生机制密切相关。临床麻醉剂量的异丙酚对ＥＴ有明显的拮抗效应，可明显提高ＡＣＩ患者体内ＣＧＲＰ水平而具有脑保护作用 Objective To investigate the effect of propofol on plasma endothelin (ET) and calcitonin gene related peptide (CGRP) during craniotomy in patients with craniocerebral injury. Methods Forty patients with acute craniocerebral injury (ACI) were randomly divided into observation group (propofol group, n = 20, group A) and control group (n = 20, group B). The plasma ET and CGRP levels in 40 patients with ACI before and after anesthesia were measured by radioimmunoassay, and 40 healthy blood donors were used as preoperative control. Results The preoperative ET and ET / CGRP in patients with ACI were significantly higher than those in the control group (P <001). At 2 hours after anesthesia, ET in group A decreased significantly (P <001) and that in group B increased significantly (P <001) before anesthesia. At 4 hours after anesthesia, the ET, ET / CGRP was lower than before anesthesia (P <001), while CGRP was significantly higher than that before anesthesia and significantly higher than that of the normal control group. However, ET in group B was significantly higher than that before anesthesia (P <001), there was significant difference between groups (P <001). Conclusion The changes of ET content in plasma are closely related to the pathogenesis of secondary brain injury after craniocerebral injury. The clinical anesthetic dose of propofol has a significant antagonistic effect on ET, which can significantly improve the level of CGRP in patients with ACI and have a protective effect on the brain