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目的 探讨ｐ５３ 蛋白在甲状腺癌（ Ｔ Ｃ）中的表达及其与细胞增殖状态和预后的关系。方法 应用免疫组化技术检测 ８１ 例 Ｔ Ｃ中ｐ５３ 蛋白表达，分析其与肿瘤细胞增殖活性（ Ｐ Ｃ Ｎ Ａ）及临床病理特性的关系。结果 ｐ５３蛋白阳性２６ 例（３２．１％ ），对照组无１ 例阳性。ｐ５３ 蛋白表达与 Ｐ Ｃ Ｎ Ａ 指数（ Ｐ＜ ０．０１）、肿瘤分化类型（ Ｐ＜ ０．０５）、浸润深度（ Ｐ＜ ０．０１）及生存期（ Ｐ＜ ０．０５）密切相关。结论 ｐ５３ 蛋白与 Ｔ Ｃ的细胞分化、增殖和浸润特性有关，该蛋白过度表达是肿瘤预后差的指标之一。
Objective To investigate the expression of p53 protein in thyroid carcinoma (TC) and its relationship with cell proliferation status and prognosis. Methods Immunohistochemical technique was used to detect the expression of p53 protein in 81 cases of T C . The relationship between the expression of p53 protein and the proliferative activity of tumor cells (P C N A) and clinicopathological features was analyzed. Results 26 cases (32.1%) were positive for p53 protein, but none was positive in the control group. There was a close relationship between p53 protein expression and PCNA index (P<0.01), tumor differentiation type (P<0.05), depth of invasion (P<0.01) and survival period (P<0.05). Conclusion The p53 protein is related to cell differentiation, proliferation and infiltration characteristics of T C. Overexpression of p53 protein is one of the indicators of poor prognosis of tumors.