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本文采用放免法测定实验性犬心肌梗塞和溶栓后再闭塞时血浆中GMP-140、TXB_2、6-K-PGFl_α的含量变化,并探讨其与心肌梗塞溶栓后再闭塞的关系。结果表明,在血栓形成时血浆中TXA_2稳定代谢产物TXB_2水平显著升高(p<0.05),在溶栓后再闭塞率高(87.5％)的非治疗组(B组),在溶栓后4小时至溶栓后3天期间呈进行性升高(p<0.01),而在再闭塞率低(16.7％)的API0134治疗组(A组)溶栓后4小时即较血栓形成时明显下降,且呈逐渐下降趋势(p<0.01),3天后已接近正常水平,而血浆中GMP-140水平在血栓形成时,溶栓后4小时～3天期间均明显升高(p<0.05),B组在30天时血浆中GMP-140仍升高(p<0.05),而A组在用API0134 30天时血浆中GMP-140已接近正常水平,血浆中6-K-PGFl_α水平在A、B两组之间及各不同时间均无明显差异。提示血浆GMP-140水平与TXB_2在血栓形成和再闭塞过程中变化趋势相似,动态测定GMP-140和TXB_2对于溶栓后再闭塞的发生可能有一定的预报价值,同时也可能为临床上判断溶栓后再闭塞提供一项新的诊断指标。
In this paper, the content of GMP-140, TXB_2, 6-K-PGFl_α in experimental canine myocardial infarction and reoperation after thrombolysis was measured by radioimmunoassay, and the relationship between GMP-140, TXB_2, The results showed that the level of TXB_2, a stable metabolite of TXB_2, was significantly increased in patients with thrombosis (p <0.05). After thrombolysis, the reocclusion rate was high (87.5%) in non-treatment group (B) (P <0.01) during the first 3 hours after thrombolysis and decreased significantly at 4 hours after thrombolysis in the group treated with API0134 (16.7%) with low reocclusion rate (group A) (P <0.01). After 3 days, the level of GMP-140 in thrombosis was significantly increased (P <0.05), while the level of GMP-140 in plasma was significantly increased from 4 hours to 3 days after thrombolysis The level of GMP-140 in plasma was still elevated at 30 days in group A (p <0.05), while the level of GMP-140 in group A was nearly normal at 30 days after treatment with API0134. The level of 6-K-PGF1α in plasma was higher in groups A and B And no significant difference between different time. It is suggested that the changes of plasma GMP-140 level and TXB_2 in thrombus formation and reocclusion are similar. Dynamic determination of GMP-140 and TXB_2 may have some predictive value for the occurrence of reoperation after thrombolysis, Re-occlusion after plug provides a new diagnostic indicator.