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目的探讨沙漠干热环境负重行军者NO和一氧化氮合酶(NOS)与生理应激的关系。方法 60名战士在沙漠干热环境中负重15 kg分别以3.5和5.0 km/h行军1、2、3 h,检测试验组和对照组战士血浆中NO含量和NOS活力、心律增值、肛温增值和积热指数。结果所有行军时间组NO(17.26~23.28μmol/L)含量均明显低于对照组(31.84μmol/L)(P<0.05),心率增值(7.6~23.9次/min)均明显高于对照(1.2次/min)(P<0.05)。15 kg负重3.5 km/h行军时,行军3 h组NO(17.26μmol/L)含量明显低于行军1 h组(22.62μmol/L)和2 h组(23.10μmol/L)(P<0.05);行军1 h组NOS(47.35 U/L)活力明显高于行军3 h组(40.90 U/L)和对照组(40.89 U/L)(P<0.05);行军3 h组肛温增值(0.17℃)明显高于行军1 h组(0.02℃)和对照组(0.00℃)(P<0.05);行军1和2 h组积热指数(-18.94~-18.31 kJ/m2)明显低于行军3 h组(22.67 kJ/m2)和对照组(0.41 kJ/m2)(P<0.05),行军3 h组积热指数明显高于对照组(P<0.05)。15 kg负重5.0 km/h行军时,行军2 h组NOS(39.44 U/L)活力明显低于对照组(40.89 U/L)和其他行军时间组(34.23~40.43U/L)(P<0.05);行军1 h组(23.9次/min)和3 h组(21.3次/min)心率增值明显高于行军2 h组(7.6次/min)(P<0.05);机体肛温随行军时间的延长而增高;各行军组积热指数(51.04~71.12 kJ/m2)明显高于对照组(0.41 kJ/m2)。结论在沙漠干热环境中行军者血浆中NO含量和NOS活力与热应激有关,沙漠干热环境劳动强度以不超过重度为宜,持续劳动时间不应超过2 h。
Objective To investigate the relationship between NO and nitric oxide synthase (NOS) and physiological stress among marchers under dry and hot desert environment. Methods 60 soldiers in the dry and hot environment of 15 kg in weight were 3.5 and 5.0 km / h marching for 1, 2 and 3 h, respectively. The plasma concentrations of NO and NOS in test group and control group were measured. And product heat index. Results The contents of NO (17.26 ~ 23.28μmol / L) in all march time groups were significantly lower than those in control group (31.84μmol / L) (P <0.05) Times / min) (P <0.05). The content of NO (17.26μmol / L) in march 3 h group was significantly lower than that in march 1 h group (22.62 μmol / L) and 2 h group (23.10 μmol / L) at 15 kg load of 3.5 km / h ; The activity of NOS (47.35 U / L) in march 1 h was significantly higher than that in march 3 h (40.90 U / L) and control group (40.89 U / L) (P <0.05) ℃) was significantly higher than that of the march 1 h group (0.02 ℃) and the control group (0.00 ℃) (P <0.05). The cumulative heat index (-18.94 ~ -18.31 kJ / m 2) (22.67 kJ / m2) and control group (0.41 kJ / m2) (P <0.05). The cumulative heat index at 3 h after march was significantly higher than that of the control group (P <0.05). At 15 kg load and 5.0 km / h march, the activity of NOS (39.44 U / L) in march 2 h group was significantly lower than that in control group (40.89 U / L) and other march groups (34.23-40.43U / L) ). The value of heart rate increased significantly in march 1 h group (23.9 times / min) and in 3 h group (21.3 times / min) than that in march 2 h group (7.6 times / min) (P <0.05) (51.04 ~ 71.12 kJ / m2) of each march group was significantly higher than that of the control group (0.41 kJ / m2). CONCLUSIONS: The NO content and NOS activity in the plasma of marchers are related to heat stress in desert dry-hot environment. The labor intensity in desert dry-hot environment should not exceed severe degree, and the duration of continuous labor should not exceed 2 hours.