Burrows 和 Bacon 二氏确定有毒的鼠疫杆菌和假结核杆菌产生两种抗原(命名为 V 和W)。而大多数无毒菌株不产生。V~+W~+菌株有抵抗细胞的吞噬作用,用 V~+W+菌株接种小白鼠比甩 V~-W~-菌株接种小白鼠对鼠疫产生比较好的保护。关于每种抗原活性的直接证据取决于对它们的分离和提纯。本文扼要的报告 V 和 W 抗原的生物合成、分离、提纯和保护作用的实验研究。 Burrows and Bacon II identified two antigens (named V and W) for the virulent Yersinia pestis and Pseudomonas sp. Most non-toxic strains are not produced. V ~ + W ~ + strains have phagocytosis of cells, V ~ + W + strains vaccinated mice than V ~ -W ~ - strains inoculated mice to plague better protection. Direct evidence regarding the activity of each antigen depends on their isolation and purification. This article briefly reports the experimental studies on biosynthesis, isolation, purification, and protection of V and W antigens.