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目的:探讨尿中纤维蛋白降解产物在诊断膀胱癌中的意义,寻求对人群进行膀胱癌筛查的简易、有效的方法。方法:以乳胶凝集半定量测定法分别测定正常人、良性血尿患者、膀胱癌患者各50人尿中FDP浓度。结果:正常对照组中42例尿FDP<2μg/ml、8例2μg/ml;良性血尿组尿FDP浓度35例<2μg/ml、12为2μg/ml、3例4μg/ml;膀胱癌组:6例2μg/ml、11例4μg/ml、26例8μg/ml、7例16μg/ml。膀胱癌组与正常对照组和良性血尿组之间FDP浓度具有显著性差异。进行比较,(P值分别为<0.01、<0.05)。结论:检测尿FDP浓度是一种简单有效的检出膀胱癌的方法,可望用于健康人群普查以便于早期发现膀胱癌。
Objective: To investigate the significance of urinary fibrin degradation products in the diagnosis of bladder cancer and to find a simple and effective method for screening bladder cancer in the population. Methods: Urinary concentrations of FDP in urine of 50 normal individuals, benign hematuria patients and bladder cancer patients were determined by semi-quantitative latex agglutination test. Results: In normal control group, the urinary FDP concentration in 2 cases was 2μg / ml in 42 cases and 2μg / ml in 8 cases; the urinary FDP concentration in benign hematuria group was 35μg / ml, 2μg / ml in 12 cases and 4μg / ml in 3 cases; 6 cases of 2μg / ml, 11 cases of 4μg / ml, 26 cases of 8μg / ml, 7 cases of 16μg / ml. There was a significant difference in FDP concentration between bladder cancer group and normal control group and benign hematuria group. (P <0.01, <0.05 respectively). Conclusion: Detecting urinary FDP concentration is a simple and effective method to detect bladder cancer. It is expected to be used for screening of healthy people in order to detect bladder cancer early.