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目的分析丙戊酸钠缓释片治疗老年癫痫患者的疗效与安全性。方法选取2013年7月—2015年11月在本院就诊的老年癫痫患者70例,将其随机分为2组,每组各35例。对照组给予托吡酯治疗,观察组给予丙戊酸钠缓释片治疗,对比分析2组疗效、不良反应及认知功能。结果对照组的治疗总有效率为77.1%,明显低于观察组的94.3%,差异有统计学意义(P<0.05);对照组的不良反应率为25.7%,明显高于观察组的8.6%,差异有统计学意义(P<0.05);治疗后对照组的认知功能(瞬时记忆、瞬时记忆、长期记忆)得分均明显低于观察组,差异有统计学意义(P<0.05)。结论给予老年癫痫患者丙戊酸钠缓释片治疗的效果显著,可明显缓解患者的病情,提高认知功能,促进预后,且应用安全性高。
Objective To analyze the efficacy and safety of sodium valproate sustained release tablets in elderly patients with epilepsy. Methods Seventy elderly patients with epilepsy were selected from July 2013 to November 2015 in our hospital. They were randomly divided into two groups (n = 35 in each group). The control group was treated with topiramate. The observation group was treated with sodium valproate sustained-release tablets. The curative effect, adverse reaction and cognitive function were compared between the two groups. Results The total effective rate of the control group was 77.1%, which was significantly lower than 94.3% of the observation group (P <0.05). The adverse reaction rate of the control group was 25.7%, which was significantly higher than that of the observation group (8.6% (P <0.05). After treatment, the scores of cognitive function (instantaneous memory, transient memory, long-term memory) in the control group were significantly lower than those in the observation group (P <0.05). Conclusions The treatment of elderly patients with epilepsy sodium valproate sustained release tablets significant effect, can significantly alleviate the patient’s condition, improve cognitive function and promote prognosis, and the application of high safety.