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从埃及伊蚊获取彭亨丝虫感染期动虫,皮下或腹腔注入沙鼠,尸检时从淋巴、心肺、睾丸及腹腔寻找成虫,血液检查微丝蚴。选择8周龄雄性沙鼠,以氟苯咪唑(FMBZ)一次量25mg/kg加1%吐温80蒸馏水配成悬液注入沙鼠背侧面皮下。沙鼠给予一次单剂量FMBZ注射63天后分5次接种感染期幼虫(L_3),每次50条,于投药后137天再用50条L_3进行攻击,隔61～75天解剖沙鼠。实验分4组:A组7只沙鼠,给予FMBZ处理和“免疫”感染,不进行L_3攻击;B组12只沙鼠,用FMBZ处理,不感染,但接受L_3攻击;C组
Obtained from the Aedes aegypti mosquito infection pest, subcutaneous or intraperitoneal injection of gerbils, autopsy from the lymphatic, cardiopulmonary, testicular and abdominal cavity looking for adult, blood microfilaria check. Eight-week-old male gerbils were selected and infused with FMBZ 25mg / kg plus 1% Tween 80 distilled water into the dorsal surface of the gerbil. The gerbils were given a single dose of FMBZ injection 63 days after inoculation of infection larvae (L_3), each time 50, 137 days after administration of 50 L_3 attack, every 61 to 75 days dissected gerbils. The experiment was divided into 4 groups: 7 gerbils in group A were given FMBZ treatment and “immunized” infection without L 3 attack; 12 gerbils in group B were treated with FMBZ without infection but under L 3 challenge; group C