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大鼠尼古丁依赖对中枢阿片系统的影响徐江平任爱国刘传缋军事医学科学院毒物药物研究所北京１００８５０大鼠连续皮下注射尼古丁，剂量由０．５ｍｇｋｇ－１至４ｍｇｋｇ－１，计９ｄ；末次给药后１～２ｈ，皮下注射４ｍｇｋｇ－１纳洛酮，，可激发依赖大鼠产生阿片戒断样...
Effects of nicotine dependence on central opioid system in rats Xu Jiang-ping Ren ai-guo Liu Chuan-hu Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences Beijing 100850 Rats were injected subcutaneously with nicotine at a dose of 0.5 mg kg -1 to 4 mg kg -1 for 9 days. After the last administration 1 ~ 2h, subcutaneous injection of 4mgkg-1 naloxone, can stimulate the dependence of rats to produce opiate withdrawal ...