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目的分析多药耐药相关蛋白(multidrug resistance-associated protein,MRP)在鼻咽癌中的表达以及N分期、病理分化程度与鼻咽癌颈淋巴结放疗敏感性关系,探讨多因素对肿瘤放疗敏感性的影响。方法采用免疫组化S-P法检测鼻咽癌组织中MRP的表达,采用多元Logistic回归分析法,分析MRP的表达、N分期、病理分化程度与鼻咽癌颈淋巴结放疗敏感性的关系。结果鼻咽癌中MRP阳性表达率为66.7%(30/45)。N1分期放疗敏感性高于其他N分期(N2-3),差异有显著性(P<0.05),但复查CT时差异无显著性(P>0.05),其他N分期(N2-3)之间差异无显著性(P>0.05);MRP阳性表达者,在DT50 Gy时临床肿瘤完全缓解率和放疗结束时复查CT的肿瘤残存率,与阴性表达之间差异无显著性(P>0.05),但在放疗结束时临床肿瘤残存率与阴性表达之间差异有显著性(P<0.05);低分化鳞癌和中分化鳞癌颈淋巴结放疗敏感性差异无显著性(P>0.05)。结论鼻咽癌组织中有较高水平的MRP表达。在鼻咽癌颈淋巴结放疗敏感性的预测上,N分期和MRP的表达有一定的指导意义,病理分化程度则无明显临床指导意义。
Objective To analyze the expression of multidrug resistance-associated protein (MRP) in nasopharyngeal carcinoma (NPC) and the relationship between N stage, pathological differentiation and radiosensitivity of cervical lymph node in nasopharyngeal carcinoma (NPC) Impact. Methods The expression of MRP in nasopharyngeal carcinoma tissues was detected by immunohistochemical S-P method. The relationship between MRP expression, N stage, pathological differentiation and radiosensitivity of nasopharyngeal carcinoma was analyzed by multivariate Logistic regression analysis. Results The positive rate of MRP in nasopharyngeal carcinoma was 66.7% (30/45). The sensitivity of stage N1 radiotherapy was higher than that of other N stages (N2-3) (P <0.05), but there was no significant difference between the two groups (P> 0.05) There was no significant difference between the two groups (P> 0.05). There was no significant difference between the MRP positive expression rate and the negative expression rate (P> 0.05) at the complete remission rate of clinical tumor at DT50 Gy and at the end of radiotherapy. However, there was a significant difference (P <0.05) between the residual tumor rate and the negative expression at the end of radiotherapy. There was no significant difference in the radiosensitivity of cervical lymph node between poorly differentiated squamous cell carcinoma and moderately differentiated squamous cell carcinoma (P> 0.05). Conclusion There is a high level of MRP expression in NPC tissues. In the prediction of radiosensitivity of cervical lymph node in nasopharyngeal carcinoma, N stage and MRP expression have some guiding significance, and the degree of pathological differentiation has no obvious clinical significance.