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深部或播散性真菌感染是血液系统恶性肿瘤和免疫缺陷患者的重要致死原因。骨髓移植(BMT)患者由于重度免疫抑制、持续性中性白细胞减少、广泛应用广谱抗生素等原因,易于发生真菌感染。鼻窦真菌感染大多由曲霉菌引起,可迅速向眶内和颅内侵犯,预后不良。 对1986～1992年间423例BMT患者回顾分析,8例(5例急性白血病,3例重度再生障碍性贫血)发生鼻脑曲霉菌病(RA)。其中5例为同种异体移植,2例
Deep or disseminated fungal infections are an important lethal cause of hematological malignancies and immunodeficiencies. Patients with bone marrow transplantation (BMT) are susceptible to fungal infections due to severe immunosuppression, persistent neutropenia, and the widespread use of broad-spectrum antibiotics. Most of sinus fungal infections caused by Aspergillus, can be quickly to the orbital and intracranial invasion, the prognosis is poor. A retrospective analysis of 423 patients with BMT between 1986 and 1992 showed that nasal aspergillosis (RA) occurred in 8 patients (5 acute leukemias and 3 severe aplastic anemia). Five of them were allografts, two cases