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雌激素可使鼻超敏反应加重，鼻粘膜肥大细胞有雌二醇受体存在。为寻找鼻粘膜高反应性炎症治疗新靶点进行本项研究。观察预先灌服雌二醇受体括抗剂——他莫西芬（tamoxifen）再给以高剂量雌二醇的动物对二异氰酸酯（TDI）激发鼻腔的反应，结果发现此类动物鼻部反应和鼻粘膜组织学改变均显著不如未经他莫西芬预处理的动物。为他莫西芬治疗某些异病提供了实验依据。
Estrogen can aggravate nasal hypersensitivity, nasal mucosal mast cells have estradiol receptors. This study was conducted to find new targets for the treatment of nasal mucosal hyper-reactive inflammation. To observe the response of tamsoxifen to high-dose estradiol-induced asthma in response to diisocyanate (TDI) -initiated nasal cavity in rats. The nasal reaction of these animals was observed And histological changes of nasal mucosa were significantly less than those without tamoxifen pretreatment. Tacoxifen for the treatment of certain diseases provide experimental evidence.