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目的探讨北京部分城区队列人群基线血压水平(1992年)及10年后(2002-2003年)血压的变化与血清肌酐(Scr)水平的关系。方法1992年对北京大学社区和首钢地区35- 64岁人群进行心血管疾病危险因素的调查,取得了基线数据。2002年对上述人群(45-74岁)进行复查,复查中加入了Scr检测指标。对两次资料完整的2740人基线血压水平及10年后血压变化与Scr水平的关系进行分析。结果(1)北京部分城区45-74岁人群平均Scr水平为(87．52±20.33)μmol／L,男性Scr[(96．36±15．92)μmol／L]高于女性[(80.44±21．22)μmol／L] (P<0．01)。(2)上述人群中Scr水平异常的发病率为8．7％,男性(13．6％)高于女性(4．4％)(P< 0．01)。其中,肾功能受损的发病率为0．9％,男性(1．6％)高于女性(0．3％)(P<0．01)。(3)随着基线血压水平的升高,10年后Scr水平呈增加趋势(P<0．01)。调整性别、年龄、体质指数、血糖、总胆固醇、高密度脂蛋白胆固醇和吸烟等变量后,基线血压≥180／110mm Hg组Scr水平异常的相对危险是血压<120／80 mm Hg组的3．89倍(95％CI:1．51-10．04)。(4)Scr水平异常的发病率在1992年和2002年血压均正常的人群为6．6％;在1992年为高血压到2002年血压控制到正常的人群为12．4％;在1992年和2002年均为高血压的人群为16．9％。结论高血压与Scr水平密切相关,有效控制血压能够延缓Scr水平的上升,在一定程度上保护肾功能。
Objective To investigate the relationship between baseline blood pressure (in 1992) and blood pressure changes in 10 years (2002-2003) and serum creatinine (Scr) in cohorts of urban areas in Beijing. Methods In 1992, we investigated the risk factors of cardiovascular diseases in 35-64-year-olds in Peking University and Shougang areas and obtained baseline data. In 2002 the above-mentioned crowd (45-74 years old) carries on the review, adds the Scr detection index in the review. The baseline data of 2740 patients with two complete data sets and the relationship between changes of blood pressure and Scr levels after 10 years were analyzed. Results (1) The average level of Scr in 45-74-year-olds in urban areas of Beijing was (87.52 ± 20.33) μmol / L, and that of male was 96.6 ± 15.92 μmol / L, 21.22) μmol / L] (P <0.01). (2) The incidence of abnormal Scr levels was 8.7% in men and 13.6% in men (4.4%) (P <0.01). Among them, the incidence of impaired renal function was 0.9%, male (1.6%) higher than female (0.3%) (P <0.01). (3) With the increase of baseline blood pressure, the level of Scr tended to increase after 10 years (P <0.01). Adjusting for gender, age, body mass index, blood glucose, total cholesterol, high-density lipoprotein cholesterol, and smoking and other variables, the relative risk of abnormal Scr levels at baseline blood pressure ≥180 / 110 mm Hg was 3 for blood pressure <120/80 mm Hg. 89-fold (95% CI: 1.51-10.04). (4) The prevalence of abnormal Scr levels was 6.6% among those with normal blood pressure in 1992 and 2002, 12.4% in those with high blood pressure in 1992 and those with normal blood pressure in 2002 and those with normal blood pressure in 2002 And 16.9% of those with hypertension in 2002. Conclusions High blood pressure is closely related to Scr level. Effective blood pressure control can delay the increase of Scr level and protect renal function to a certain extent.