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目的:了解尿α1-MG、尿β2-MG对系统性红斑狼疮(SLE)患者肾损害的诊断价值。方法:通过双抗体夹心酶联免疫法(ELISA)对60例SLE患者与20例健康对照组的尿α1-MG、尿β2-MG进行检测。结果:LN患者尿α1-MG、尿β2-MG明显高于正常对照组(P<0.01);随着病程的延长,SLE患者的尿α1-MG、尿β2-MG逐渐升高。结论:尿α1-MG、β2-MG是反映SLE肾损害可靠的指标,能够较准确地反映肾小管间质损害严重程度。
Objective: To investigate the diagnostic value of urinary α1-MG and urinary β2-MG on renal damage in patients with systemic lupus erythematosus (SLE). Methods: Urine α1-MG and urinary β2-MG in 60 SLE patients and 20 healthy controls were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results: The urinary α1-MG and urinary β2-MG in patients with LN were significantly higher than those in normal controls (P <0.01). Urine α1-MG and urinary β2-MG increased gradually in patients with SLE. Conclusion: Urine α1-MG and β2-MG are reliable indicators of renal damage in SLE and can reflect the severity of tubulointerstitial damage more accurately.