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目的探讨妊娠对兔骨折愈合的影响。方法日本大耳白雌兔随机分成对照组、妊娠组,对照组不做处理,妊娠组交配受孕,妊娠组孕后9d分组造模成左小腿中段闭合骨折模型,按造模前、造模后即时、造模后1、2、3周各时点抽取耳缘静脉血或心穿血,提取血清后-80℃冻存。按时点计算机数字化X线成像(Computed radiography,CR)、骨密度检查,其数据行统计学检验。结果妊娠组造模后1、2、3周骨痂骨密度值[(0.456±0.019)、(0.469±0.016)、0.461±0.022)g/cm2]、骨痂骨矿质含量值[(0.773±0.103)、(0.968±0.140)、(1.127±0.213)g]均高于对照组[(0.347±0.039)、(0.372±0.039)、(0.409±0.021)g/cm2]、;(0.617±0.083)、(0.783±0.062)、(0.998±0.087)g](P﹤0.05);CR定量测得的骨痂平均光密度值,妊娠组造模后1、2、3周均高于对照组(P﹤0.05)。结论兔早中期妊娠可能对骨折愈合有促进作用。
Objective To investigate the effect of pregnancy on fracture healing in rabbits. Methods Japanese white male white rabbits were randomly divided into control group, pregnancy group and control group without treatment. Pregnancy group mating pregnancy, pregnancy group 9d after pregnancy were grouped into the left calf middle closed fracture model, according to the model before and after modeling Instant, 1, 2 and 3 weeks after the model was drawn at each time point of the ear vein or heart blood, extracted serum -80 ℃ frozen. Time-point computerized digital radiography (Computed radiography, bone mineral density examination, the data line statistical test. Results The bone mineral density of callus in the gestation group [(0.456 ± 0.019), (0.469 ± 0.016), 0.461 ± 0.022g / cm2], and [ ), (0.968 ± 0.140) and (1.127 ± 0.213) g were significantly higher than those in the control group [(0.347 ± 0.039), (0.372 ± 0.039) and (0.409 ± 0.021) g / (0.783 ± 0.062) and (0.998 ± 0.087) g, respectively (P <0.05). The average callus calculus value of CR was higher than that of the control group (P <0.05) . Conclusion Early and mid-term pregnancy in rabbits may promote fracture healing.