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大量的研究发现,细胞外信号通过细胞质中的信号转导通路,可激活核转录因子即刻早期反应因子(Egr-1)的表达合成,使其进入细胞核内,调控细胞核内的相关靶基因的转录表达,使细胞产生适应性变化。因此细胞的许多生物学功能可归因于转录因子Egr-1的表达活化。本文探讨了在细胞增殖和细胞凋亡的过程中,转录因子Egr-1的生物学功能。特别是其在肿瘤性疾病发生、发展中的作用已成为近年来研究的热点。
A large number of studies have found that extracellular signals through the signal transduction pathway in the cytoplasm can activate the expression and synthesis of the nuclear transcription factor immediate response factor (Egr-1) into the nucleus and regulate the transcription of relevant target genes in the nucleus Expression, so that cells produce adaptive changes. Thus many of the biological functions of cells can be attributed to the activation of the expression of the transcription factor Egr-1. This article explored the biological functions of the transcription factor Egr-1 during cell proliferation and apoptosis. In particular, its role in the occurrence and development of neoplastic diseases has become a hot spot in recent years.