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目的:对甘肃省水痘疫苗接种进行成本效益分析,为今后制定水痘防控策略提供参考依据。方法:设定三种免疫策略,即未予以免疫接种、策略Ⅰ常规免疫(1岁时接种1剂次水痘疫苗)、策略Ⅱ常规免疫+加强免疫(1岁和12岁各接种1剂次水痘疫苗)、策略Ⅲ常规免疫+强化免疫(2-15岁强化免疫1剂次及1岁接种1剂次水痘),利用EVITA模型评价成本效益,推算15年的水痘发病情况、经济负担、BCR值和NPV值。结果:未予以免疫接种:15年累计发病5 301 764例;策略Ⅰ:BCR=0.744,NPV=-0.98;策略Ⅱ:BCR=0.595,NPV=-6.19;策略Ⅲ:BCR=1.518,NPV=0.49。以策略Ⅲ的BCR值最高,BCR>1且NPV>0,说明该策略可接受,成本效益最好。结论:常规免疫+强化免疫的免疫接种策略是水痘预防控制的最佳方案。
OBJECTIVE: To analyze the cost-benefit of chickenpox vaccination in Gansu Province and provide a reference for the future development of chickenpox prevention and control strategy. Methods: Three immunization strategies were set up, namely, immunization was not given, strategy I was routinely immunized (one dose of varicella vaccine was administered at the age of one year), strategy II was routinely immunized and boosted (one dose of varicella Vaccine), Strategy III routine immunization + intensive immunization (2-15 years of intensive immunization and 1-year-old vaccination of 1 case of chickenpox), EVITA model was used to evaluate the cost-effectiveness and the 15-year incidence of chickenpox, economic burden, BCR value And NPV values. Results: No immunization: cumulative incidence of 5 301 764 cases in 15 years; Strategy Ⅰ: BCR = 0.744, NPV = -0.98; Strategy Ⅱ: BCR = 0.595, NPV = . The highest BCR value for Strategy III, BCR> 1 and NPV> 0, indicates that this strategy is acceptable and cost-effective is the best. Conclusion: The immunization strategy of routine immunization and intensive immunization is the best way to prevent and control chickenpox.