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ＮＩＨ系孕鼠２１只，随机分为正常组和给药组。给药组于妊娠第１２天腹腔内注射５０ｍｇ／ｋｇＤｅｘａｍｅｔｈａｓｏｎｅａｃｅｔａｔｅ，干扰鼠胚腭器官发育。二组孕鼠分别于妊娠第１２／１２、１３／１２、１４／１８、１５／１０、１５／１８、１６／０、１６／１８天／小时处死，共获得胚胎１８４只。取头部标本作冠状切片，ＨＥ染色，光镜观察，对鼠腭器官的发育进行研究。提出了腭器官发育的六个时期．并认为妊娠第１３／２天／；小时～１４／１８天／小时是腭突上抬及水平生长期，腭突上抬延迟是腭裂产生的主要因素之一。
Twenty-one NIH pregnant rats were randomly divided into normal group and administration group. The dosing group was intraperitoneally injected with 50mg / kgDexamethasoneacetate on the 12th day of gestation to interfere with the development of palatal palatal. Two groups of pregnant rats were sacrificed 12th, 12th, 12th, 12th, 14th, 18th, 15th, 15th, 18th, 16th and 16th day respectively. 184 embryos were obtained. Take the head specimens for coronal section, HE staining, light microscope observation, the development of mouse palatal organs. Proposed palatal organ development in six periods. And that the first 13/2 days of pregnancy /; hours ~ 14/18 days / hour is the palatal uplift and horizontal growth stage, delayed upward palatal protrusion is one of the main factors of cleft palate.