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氟嗪酸(ofloxacin)是一种喹诺酮类广谱抗生素。本文报告用氟嗪酸或乙胺丁醇(EMB)与雷米封(INH)和利福平(RFP)联合治疗初治肺结核患者的研究结果。方法选择1986年1月～1988年5月入院的痰涂片或培养阳性肺结核患者共124例,随机分成两组,分别用 EMB(1g/d)或氟嗪酸加用 RFP(0.45/d)和 INH(0.4/d),开始两个月氟嚓酸用量为0.6/d,后7个月为0.3/d,疗程9个月。每个月复查 X 线、痰涂片和痰培养、血、尿常规等结果治疗3个月后,用氟嗪酸组胸部 X线好转率36%,用 EMB 组50%,两组无差异;治疗6个月后,用氟嗪酸组胸部 X 线改善率66%,
Ofloxacin is a quinolone broad-spectrum antibiotic. This article reports the results of a study of patients with newly diagnosed pulmonary tuberculosis treated with either flurazin or ethambutol (EMB) in combination with renin (INH) and rifampicin (RFP). Methods A total of 124 patients with sputum smear or positive pulmonary tuberculosis who were admitted to hospital from January 1986 to May 1988 were randomly divided into two groups and treated with EMB (1g / d) or flurazinic acid plus RFP (0.45 / d) And INH (0.4 / d) for the first two months. The dosage of VFK was 0.6 / d in the first two months, 0.3 / d in the last 7 months, and the course of treatment was 9 months. Every month review of X-ray, sputum smear and sputum culture, blood, urine and other results after treatment for 3 months, withloxacin group chest X-ray improvement rate of 36%, with EMB 50%, no difference between the two groups; After 6 months of treatment, the improvement rate of chest X-ray with fluorozinc acid group was 66%