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在60年代及70年代初期,医生们已常规应用雌激素治疗阵发性发热、盗汗和其他绝经期症候群。但是,到70年代中期,随着妇女服用雌激素后,出现子宫内膜癌及乳腺癌发病率较高的报道,使雌激素的声誉受到影响,虽然雌激素是否能诱发癌肿仍未弄清楚,但对绝经期后妇女大规模的研究显示:服用雌激素的妇女与从未服用雌激素的妇女相比较,前者患致命性或非致命性冠心病的危险减少了一半。这个结论是波士顿哈佛公共卫生学院Stampfer,M.J.领导的一组研究人员,通过进行年龄及其他心血管病因素的研究统
In the 1960s and early 1970s, doctors routinely used estrogen to treat paroxysmal fever, night sweats and other menopausal syndromes. However, by the mid-1970s, reports of higher rates of endometrial cancer and breast cancer after women took estrogen had affected the reputation of estrogen, although it remains unclear whether estrogen can induce cancer , Large-scale studies of postmenopausal women show that women who take estrogen have a 50% reduction in the risk of fatal or nonfatal coronary heart disease compared with women who have never taken estrogen. This conclusion is led by a group of researchers led by Stampfer, M.J., of the Harvard School of Public Health in Boston, who, through the study of age and other cardiovascular factors