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本文对60例经纤维支气管镜检查未能确诊的肺癌患者(腺癌44例、扁平上皮癌14例、小细胞癌2例)作了病灶局部支气管灌洗术和细胞刷检查。病灶局部支气管灌洗方法:纤维支气管镜插入病灶所在的支气管段或亚段后,注入100ml 生理盐水。然后以90mmHg的负压抽吸灌洗液。将所收集的支气管灌洗液经1,500rpm×5min 离心后,其沉渣部分送常规细胞学检查,其上清部分进行癌胚抗原(CEA)浓度测定。结果本组患者经病灶局部支气管灌洗液细胞学检查,诊断阳性率达63%,细胞刷检查的诊断阳性率为77%。14例经细胞刷检查结果阴性者中6例经支气管灌洗术确诊,同时应用支气管灌洗术和细胞刷检
In this study, 60 cases of lung cancer patients (adenocarcinoma in 44 cases, squamous cell carcinoma in 14 cases, and small cell carcinoma in 2 cases) who were not diagnosed by fiberoptic bronchoscopy were treated with focal bronchoalveolar lavage and cytology. Intralesional bronchoalveolar lavage method: After a fiberoptic bronchoscope is inserted into the bronchial segment or subsegment where the lesion is located, 100ml normal saline is injected. The lavage fluid was then aspirated with a negative pressure of 90 mmHg. After the collected bronchial lavage fluid was centrifuged at 1,500 rpm for 5 minutes, the sediment was partially sent for routine cytological examination, and the supernatant fraction was subjected to the determination of carcinoembryonic antigen (CEA) concentration. RESULTS: In this group of patients, the bronchial lavage fluid cytological examination of the lesions showed a positive diagnostic rate of 63%, and a positive rate of cytology was 77%. Sixteen of the 14 cases who were negative by cytobrush test were confirmed by bronchial lavage, while bronchial lavage and cell brushing were used.