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目的 1.观察就诊于我院的孕妇血浆D-二聚体水平的变化趋向,明确妊娠因素对孕妇血浆D-二聚体水平的影响。2.建立吕梁市健康孕妇不同孕期D-二聚体的参考区间。3.探讨本研究所确立的参考区间对产科凝血止血相关疾病诊疗的指导意义。方法选取2016年7月至2017年2月就诊于山西省汾阳医院的健康孕产妇632例、健康非孕妇女100例、DIC孕妇10例、静脉血栓孕妇15例,运用胶乳免疫比浊法定量检测其血浆D-二聚体的浓度。以健康孕妇的检测数据制定D-二聚体的相应参考区间,并和所选健康非孕妇女、DIC孕妇、静脉血栓孕妇的检测数据进行比对分析。结果 1.孕妇血浆D-二聚体水平显著高于非孕妇女人群,现阶段临床检验科室所使用的D-二聚体疾病界定值主要针对的是非孕人群,不适用于孕妇群体;孕妇血浆D-二聚体水平随孕周增加而逐渐增高。2.吕梁市健康孕妇人群血浆D-二聚体的95%参考区间为:≤13w:≤0.835 mg/L;14-27w:≤1.87 mg/L;≥28w:≤2.91mg/L。3.采用本研究所制定的参考区间来评估10例DIC孕妇和15例静脉血栓孕妇的D-二聚体检测值,均判断为为阳性结果,初步验证了本研究所制定的参考区间的有效性。结论本研究初步建立了基于胶乳免疫比浊法的吕梁市孕妇血浆D-二聚体参考区间。运用该参考区间可以提高D-二聚体对孕妇人群凝血止血相关疾病的诊断价值。
Objectives 1. Observe the trend of plasma D-dimer level in pregnant women attending our hospital, and clarify the effect of pregnancy on plasma D-dimer levels in pregnant women. 2. To establish a reference interval of D-dimer in different pregnant pregnant women in Luliang city. 3. To explore the reference interval established in this study of obstetrics coagulation hemostasis associated disease diagnosis and treatment guidance. Methods From June 2016 to February 2017, 632 healthy pregnant women, 100 healthy non-pregnant women, 10 pregnant women with DIC, 15 pregnant women with venous thrombosis were enrolled in Fenyang Hospital of Shanxi Province. Quantitative latex latex The plasma D-dimer concentration was measured. The corresponding reference interval of D-dimer was established based on the test data of healthy pregnant women, and compared with the test data of healthy pregnant women, pregnant women with DIC and pregnant women with venous thrombosis. Results 1. The level of plasma D-dimer in pregnant women was significantly higher than that in non-pregnant women. The definition of D-dimer disease used in clinical laboratory at this stage is mainly for non-pregnant women and not suitable for pregnant women. Pregnant women’s plasma D-dimer levels increased with gestational weeks increased. Luliang healthy pregnant women population plasma D-dimer 95% of the reference interval: ≤13w: ≤0.835 mg / L; 14-27w: ≤1.87 mg / L; ≥28w: ≤2.91mg / L. The D-dimer values of 10 pregnant women with DIC and 15 pregnant women with venous thrombosis were evaluated by using the reference interval established in this study, which were all judged to be positive results, which validated the validity of the reference interval established in this study Sex. Conclusion This study initially established a serum D-dimer reference interval for pregnant women in Luliang city based on latex immunoturbidimetry. The use of this reference interval can improve the diagnostic value of D-dimer on coagulation and hemostasis-related diseases in pregnant women.