很早以前就知道,在同一个家系内有时发生许多肾炎患者,1874年 Samuelson 发表了关于遗传性肾炎的论文。家族性肾炎引起普遍的注意是在1927年Alport 发表了一个伴有神经性耳聋的遗传性肾炎(Alport 综合征)的家系之后。家族性肾炎有 Alport 综合征和不伴有耳聋的病型,但后者远较前者为多。根据 Ferguson 等的统计,至1971年已发表了约70个家系的 Alport 综合征。 It has long been known that many patients with nephritis sometimes develop within the same pedigree. In 1874 Samuelson published a paper on hereditary nephritis. Familial nephritis has caused widespread attention after Alport published a pedigree of hereditary nephritis (Alport syndrome) with neurological deafness in 1927. Familial nephritis has Alport syndrome and is not associated with deafness, but the latter is far more than the former. According to Ferguson et al., Alport syndrome was reported in about 70 families by 1971.