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目的探讨代谢综合征(MS)对骨量的影响。方法DEXA测定86例MS患者及89例对照者的瘦体重、总体脂量、全身脂肪含量、全身BMD及BMC,测血FINS、FPG,计算BMI、CBMC、HOMA-IR及ISI。将两组对象上述指标加以对比,分析体重及其构成成分、胰岛素抵抗指标与骨量的关系。结果MS组瘦体重、总体脂量、全身BMD、BMC、FINS、HOMA-IR大于对照组,CBMC、ISI小于对照组。在MS组资料中,瘦体重、总体脂量对BMD、BMC呈正相关,全身脂肪含量对CBMC呈负相关;FINS、HOMA-IR、ISI与骨量无相关性。结论MS患者骨量高于正常人,但可能是假阳性增高,其发生骨质疏松的危险性并未减少;瘦体重及总体脂量是其骨量保护因素,瘦体重的保护作用更显著;IR对骨量可能无明显影响。
Objective To investigate the effect of metabolic syndrome (MS) on bone mass. Methods DEXA was used to measure lean body mass, total fat mass, whole body fat content, whole body BMD and BMC, FINS, FPG, BMI, CBMC, HOMA-IR and ISI in 86 patients with MS and 89 controls. The two groups of subjects to compare the above indicators, analysis of body weight and composition, insulin resistance and bone mass relationship. Results The lean body mass, total fat mass, whole body BMD, BMC, FINS and HOMA-IR in MS group were higher than those in control group, CBMC and ISI. In the MS group, lean body mass and total fat mass were positively correlated with BMD and BMC, and body fat content was negatively correlated with CBMC. There was no correlation between FINS, HOMA-IR and ISI and bone mass. Conclusion The bone mass of MS patients is higher than that of normal people, but it may be false positive and the risk of osteoporosis does not decrease. Lean body mass and total fat mass are the protective factors of bone mass, and the protective effect of lean body mass is more significant. IR may have no significant effect on bone mass.