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目的 探究不同麻醉药对酗酒小鼠术中胃肠推进作用的影响.方法 酗酒昆明种小鼠24只,按随机分组法设计分为生理盐水组、氯胺酮组、丙泊酚组,每组8只.各组均采用炭末悬浊液灌胃(5％活性炭和10％阿拉伯树胶),计算30 min炭末悬浊液在小肠中推进距离占小肠全长的的百分比(炭末悬浊液移动率),以此作为胃肠推进运动的指标.结果 与生理盐水组相比,丙泊酚组小鼠胃肠推进率明显增加(P＜0.05);氯胺酮组小鼠胃肠推进率与生理盐水组差异无统计学意义(P＞0.05).结论 丙泊酚对酗酒小鼠术中胃肠推进运动有增强作用.“,”Objective To explore the effects of different anesthetics on the gastrointestinal motility in alcoholic mice.Methods A total of 24 alcoholic Kunming mice were randomly divided into 3 groups:a normal saline group,a ketamine group,and a propofol group (n =8).During experiments,each group was intragastrically administered with aqueous suspension containing 5％ charcoal and 10％ arabia gum.The percentage of the distance that the coal suspension was pushed in the small intestine was measured within 30 min (the movement rate of the coal suspension).Results Compared with the normal saline group,the propofol group showed a remarkably increased gastrointestinal propulsion rate (P ＜ 0.05),while no significant difference was found as to the gastrointestinal propulsion rate in the ketamine group (P ＞ 0.05).Conclusions Treatment with propofol can strengthen the gastrointestinal motility during operation in alcoholic mice.