论文部分内容阅读
文献上尚未报道大剂量~(131)I用于甲状腺癌后损害甲状旁腺.作者于1978年见一甲状腺乳头状癌女性患者,接受100mCi~(131)I和手术后颈部外放射治疗,20个月后出现明显手足搐搦,这提示~(131)I对甲状旁腺损害的可能性,为此,作者对这类病人制定了监测甲状旁腺功能的方案并作一研究.作者分析了53例甲状腺肿瘤术后病人.年龄在15～82岁,全部于住院后第一天查血钙、磷、镁、白蛋白和肌酐清除率,第2～5天用利尿酸强利尿剂作水盐负荷试验,第5天末重复上述生化检查.第6天,静脉注入2～4mCi~(131)I,第7天核素r扫描,若残留甲状腺有功能的组织,再给予80～150mCi~(131)I的摘除剂量,上述方案每4～6月重复一次直至残留功能组织完全摘除.以后每一年一次.血钙正常范围是2.10～2.50mmol/l,比较水盐负荷试验前后的血钙
The literature has not yet reported a large dose of 131I for thyroid cancer after damage to the parathyroid.A patient in 1978 saw a woman with thyroid papillary carcinoma, received 100mCi ~ (131) I and postoperative external neck radiotherapy, A significant tetany was observed after 20 months, suggesting the possibility of ~ (131) I damage to the parathyroid glands, and for this reason, the authors developed a protocol for monitoring the parathyroid function in these patients and made a study. 53 cases of thyroid tumor patients after surgery, aged 15 to 82 years old, all in the first day after admission to check calcium, phosphorus, magnesium, albumin and creatinine clearance rate, 2 to 5 days with diuretic strong diuretic for water Salt load test, repeat the biochemical examination at the end of the fifth day .On the sixth day, intravenous infusion of 2 ~ 4mCi ~ (131) I, the seventh day of radionuclide r scan, if residual thyroid tissue, then give 80 ~ 150mCi ~ (131) I removal dose, the program repeated every 4 to 6 months until the remaining functional tissue completely removed after every year. The normal range of calcium is 2.10 ~ 2.50mmol / l, compared with salt water load test before and after the blood calcium