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目的:调查伊犁州0～14岁儿童先天性心脏病(congenital heart disease,CHD)的分布情况,揭示与CHD发生有关的环境和遗传危险因素,为CHD的预防提供相关指导。方法:根据现有442例CHD患儿,并从伊犁州8县1市随机抽取884例儿童,采用2∶1配对病例对照研究方法,并采用单因素及多因素Logistic回归分析进行CHD的危险因素分析。结果:最终筛选出8个与CHD发生相关的主要危险因素。结论:怀孕早期是胎儿心脏发育的关键阶段,环境和遗传因素在CHD的发生中扮演了重要的角色,CHD的病因学研究对减少CHD的发生具有重要的意义。避免有害环境因素的接触和加强孕期保健有益于减少CHD的发生。
Objective: To investigate the distribution of congenital heart disease (CHD) in children aged 0 ~ 14 years old in Yili Prefecture, reveal the environmental and genetic risk factors related to the occurrence of CHD, and provide guidance for the prevention of CHD. Methods: According to the existing 442 children with CHD, 884 children were randomly selected from 8 counties and 1 city in Yili prefecture. The 2-to-1 matched case-control study method was used. The risk factors of CHD were analyzed by univariate and multivariate logistic regression analysis analysis. Results: Eight major risk factors related to the occurrence of CHD were finally screened out. Conclusion: Early pregnancy is a critical stage of fetal heart development. Environmental and genetic factors play an important role in the pathogenesis of CHD. Etiology of CHD plays an important role in reducing the incidence of CHD. Avoiding exposure to harmful environmental factors and enhancing prenatal care are good for reducing the incidence of CHD.