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神经发生是特定脑区神经前体细胞产生新生神经元的持续过程。癫痫主要影响海马齿状回的神经发生。本文主要根据年龄段和发病缓急综述近几年文献,阐明不同癫痫模型在痫样发作后神经发生变化的差异。同时概述了癫痫脑内神经发生的一系列调节因素包括内源性和外源性因素,及其可能作用途径:影响前体细胞增殖、分化和新生细胞的迁徙。神经发生与癫痫发病机制密切相关,但其具体意义目前尚不明确,可能是一个潜在的癫痫治疗新靶点。
Neurogenesis is a continuous process of producing newborn neurons from neural precursors of specific brain regions. Epilepsy mainly affects the neurogenesis of the hippocampal dentate gyrus. This article mainly based on age and onset of acute review of recent literature, clarify the different epilepsy model of epileptic seizures changes in neurological differences. At the same time, a series of regulatory factors of neurogenesis in the epileptic brain including the endogenous and exogenous factors and their possible pathways are also summarized: affecting the proliferation of precursor cells, differentiation and the migration of newborn cells. Neurogenesis is closely related to the pathogenesis of epilepsy, but its specific significance is not yet clear, which may be a potential new target for the treatment of epilepsy.