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在寻找新抗癌药物中,对筛选方法进行了大量的实验研究。目前最成功的实验系统就是动物的移植性肿瘤,通过它们发现了多数临床上有效的抗癌药物。现有各种化学类型和作用机理不同的抗肿瘤药物大多数对处于周期中的细胞有毒性,其生化性质也大致相似。有人提出,只有使用人体肿瘤作为试验系统,才能发现本质上属于不同类型的抗癌药物。曾对人体恶性细胞的体外培养作了充
In searching for new anticancer drugs, a large number of experimental studies have been conducted on screening methods. At present, the most successful experimental system is a transplanted tumor of animals, through which most clinically effective anti-cancer drugs are found. Currently, most of the anticancer drugs with different chemical types and mechanism of action are toxic to the cells in the cycle and their biochemical properties are similar. It has been suggested that it is only by using human tumors as a test system that one can find essentially different types of anti-cancer drugs. Once human malignant cells cultured in vitro made a charge