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在体外培养条件下观察了西咪替丁对恶性疟原虫生长的影响。当西咪替丁的浓度为５×１０－３～４×１０－２ｍｏｌ／Ｌ时，具有明显的直接杀灭疟原虫及抑制其生长的作用。进一步观察西咪替丁对恶性疟原虫红内期发育的影响，结果表明，该药对环状体期的虫体最为敏感，可致原虫数目减少，并抑制其发育成滋养体。
The effects of cimetidine on the growth of P. falciparum were observed in vitro. When the concentration of cimetidine is 5 × 10-3 ~ 4 × 10-2mol / L, it has obvious effect of directly killing Plasmodium and inhibiting its growth. The effect of cimetidine on the development of Plasmodium falciparum during the red stage was further observed. The results showed that the drug was the most sensitive to the ring body phase, reducing the number of protozoa and inhibiting its development into trophozoites.