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目的:研究益气活血解毒方对晚期结肠癌患者血清炎症因子、免疫功能及不良反应的影响。方法:选取本院2009年6月—2014年6月在院外科及肿瘤科收治的结肠癌患者130例,随机分为观察组和对照组,对照组术后接受FOLFOX-4化疗,观察组术后接受益气活血解毒方联合FOLFOX-4化疗,观察两组患者化疗过程中的不良反应,测定化疗前后炎症因子水平及免疫功能指标。结果:两组患者治疗前TNF-α、IL-6、IL-8水平对比无明显差异,具有可比性,治疗后观察组患者TNF-α、IL-6、IL-8水平分别为(15.8±2.4)、(4.5±0.9)、(5.2±0.6)明显低于对照组患者,差异显著,具有统计学意义,P<0.05;治疗后,对照组患者外周血中CD3~+CD4+CD8-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3-CD56+细胞的含量以及血清Ig M、Ig A、Ig G的含量显著低于化疗前(P<0.05),观察组患者外周血中CD3~+CD4+CD8-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3-CD56+细胞的含量以及血清Ig M、Ig A、Ig G的含量与化疗前无显著性差异(P>0.05);观察组患者治疗后外周血中CD3~+CD4+CD8-细胞、CD3~+CD4~-CD8~+细胞、CD19~+细胞、CD3-CD56+细胞的含量以及血清Ig M、Ig A、Ig G的含量显著高于对照组(P<0.05);观察组患者在化疗过程中发生消化道反应、肝功能损伤、骨髓抑制、周围神经毒性、口腔黏膜损伤、脱发的例数均显著少于对照组。结论:益气活血解毒方辅助治疗能够减轻结肠癌根治术后FOLFOX-4化疗的毒副作用、改善免疫功能,降低炎症因子,是理想的辅助治疗药物。
Objective: To study the effects of Yiqi Huoxue Jiedu Fang on serum inflammatory factors, immune function and adverse reactions in patients with advanced colon cancer. Methods: A total of 130 patients with colon cancer admitted to our hospital from June 2009 to June 2014 were randomly divided into observation group and control group. The control group received FOLFOX-4 chemotherapy after operation and the observation group After receiving Yiqi Huoxue Jiedu Fang combined with FOLFOX-4 chemotherapy, two groups of patients were observed during chemotherapy adverse reactions before and after chemotherapy to determine the level of inflammatory cytokines and immune function. Results: There was no significant difference in the levels of TNF-α, IL-6 and IL-8 between the two groups before treatment, and the levels of TNF-α, IL-6 and IL-8 in the observation group were (15.8 ± 2.4), (4.5 ± 0.9) and (5.2 ± 0.6) in the control group were significantly lower than those in the control group (P <0.05). After treatment, the levels of CD3 + CD4 + CD8- , CD3 ~ + CD4 ~ -CD8 ~ + cells, CD19 ~ + cells, CD3-CD56 + cells and serum IgM, IgA and IgG levels were significantly lower than those before chemotherapy (P < The content of CD3 ~ + CD4 + CD8- cells, CD3 ~ + CD4 ~ -CD8 ~ + cells, CD19 ~ + cells and CD3- CD56 + cells in serum and serum Ig M, Ig A, Ig G were not significantly different from those before chemotherapy (P> 0.05). The content of CD3 ~ + CD4 + CD8- cells, CD3 ~ + CD4 ~ -CD8 ~ + cells, CD19 ~ + cells and CD3-CD56 + M, Ig A, Ig G were significantly higher than those in the control group (P <0.05). The patients in the observation group had gastrointestinal reactions, liver damage, myelosuppression, peripheral neurotoxicity, oral mucosal injury and hair loss in the course of chemotherapy Numbers were significantly less than the control group . Conclusion: The adjuvant therapy of Yiqi Huoxue Jiedu Decoction can relieve the toxic side effects of FOLFOX-4 chemotherapy after colon cancer radical operation, improve immune function and reduce inflammatory factors, which is an ideal adjuvant therapy.