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目的:探讨碱性成纤维细胞生长因子(b FGF)在免疫球蛋白A(Ig A)肾病肾小管间质病变中的检验价值。方法:选取2013年2月-2014年6月我院收治的肾活检确诊为Ig A肾病肾小管间质病变患者20例为研究组,选同期20例行肾肿瘤切除患者的远离肿瘤部位的正常肾组织为对照组。所有患者均行b FGF检测,比较Ig A肾病患者不同程度肾小管间质病变的肾组织内b FGF的表达结果。结果:研究组肾间质肾小管b FGF阳性面积比值为(0.28±0.12),对照组肾间质肾小管b FGF阳性面积比值为(0.05±0.04),组间比较,差异具有统计学意义(P<0.05)。结论:b FGF与Ig A肾病肾小管间质病变关系密切,对Ig A肾病肾小管间质病变患者的临床诊断及疾病预后具有重要意义,可作为判断Ig A肾病肾小管间质病变进展及预后的重要检验指标。
Objective: To investigate the value of basic fibroblast growth factor (b FGF) in tubulointerstitial lesions of immunoglobulin A (IgA) nephropathy. Methods: Twenty patients with renal tubulointerstitial lesions of IgA nephropathy diagnosed by renal biopsy in our hospital from February 2013 to June 2014 were selected as the study group. Twenty cases of patients with renal tumor resected during the same period were excluded from the tumor site. Kidney tissue as control group. All patients underwent b FGF test to compare the expression of b FGF in renal tissues of patients with IgA nephropathy with different degrees of tubulointerstitial lesions. Results: The bFGF positive area ratio of renal tubule in experimental group was (0.28 ± 0.12) and that in control group was (0.05 ± 0.04), the difference was statistically significant P <0.05). CONCLUSION: b FGF is closely related to tubulointerstitial lesions of IgA nephropathy, which is of great significance for the clinical diagnosis and prognosis of tubulointerstitial lesions in IgA nephropathy. It can be used as a marker to judge the progression and prognosis of tubulointerstitial lesions of IgA nephropathy The important test indicators.