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高香草酸(HVA)及5-羟吲噪乙酸(5-HIAA)分别为中枢神经介质多巴胺(DA)及5-羟色胺(5-HT)之主要代谢产物,这些代谢产物在CSF中的浓度反映着CNS中DA或5-HT之浓度以及DA或5-HT能神经元之活动.从脑组织释放出来的HVA及5-HIAA进入侧脑室及第三脑室之CSF,主要通过第四脑室脉络丛被再吸收入血液中.因此这些代谢产物在侧脑室CSF中之浓度为蛛网膜下腔中的三倍.Andersson等于1966年曾观察到在脑积水患儿脑脊液中5-HIAA浓度增高,并提出这是一种早期脑积水之诊断特征,Maira等人曾报道,在有正常颅压脑积水之Hakin综合症患者中脊髓蛛网膜下腔之脑脊液HVA浓度降低,当前多数的观点认为诊断急性
HVA and 5-HIAA are the main metabolites of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the central nervous system, respectively. The concentrations of these metabolites in the CSF reflect Concentration of DA or 5-HT in the CNS and activity of DA or 5-HT neurons Neuronal release of HVA and 5-HIAA from the brain tissue into the lateral and third ventricle CSF mainly through the fourth ventricle choroid plexus Are reabsorbed into the bloodstream.Thus, these metabolites are three times more concentrated in the CSF of the lateral ventricle.5 Andersson et al., In 1966, observed an increase in the concentration of 5-HIAA in cerebrospinal fluid in children with hydrocephalus Proposed that this is an early diagnosis of hydrocephalus characteristics, Maira et al have reported, Hakin Syndrome in patients with normal intracranial pressure hydrocephalus cerebrospinal fluid HVA concentration decreased, the current view that most of the diagnosis acute