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目的探讨臂踝脉搏波传导速度(baPWV)与左心室肥厚(LVH)的关系。方法在浙江省东部沿海807名居民中,使用体积描记仪(欧姆龙-VP1000)测量baPWV,使用超声心电图测量左心室结构。以美国超声心动图学会推荐的标准定义LVH[左室质量/身高2.7≥51g/m2.7(男性)或者左室质量/身高2.7≥47g/m2.7(女性)]。结果LVH组的baPWV显著高于非LVH组[(15.3±3.3)比(13.3±2.5)m/s,P<0.01]。在807人中,没有调整其他心血管危险因素时,baPWV与左心室质量指数具有微弱相关性(r=0.19,P<0.01)。但在调整年龄和收缩压之后,二者之间的关联不再显著(r=-0.008,P=0.81)。在男性与女性中分别分析baPWV与LVH的关系,结果相似。在不调整其他心血管危险因素时,无论在男性(OR=1.30,P<0.01),还是女性(OR=1.19,P<0.05),随着baPWV的增高,LVH患病风险均增加(P<0.05)。但在调整年龄、收缩压以后,不论男性还是女性,二者的关联均未达到统计学显著性(P>0.05)。结论反映大动脉及肌性动脉硬化的baPWV与LVH之间的关联,在很大程度上和这两种亚临床病变形式共同的危险因素,如年龄、收缩压等有关。
Objective To investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and left ventricular hypertrophy (LVH). Methods BaPWV was measured by plethysmograph (OMR-VP1000) in 807 residents along the eastern coast of Zhejiang Province. The left ventricular structure was measured by echocardiography. LVH [LV mass / height 2.7 ≧ 51 g / m2.7 (men) or LV mass / height 2.7 ≧ 47 g / m2.7 (women)] was defined as recommended by the American Society of Echocardiography. Results The baPWV in LVH group was significantly higher than that in non-LVH group [(15.3 ± 3.3) vs (13.3 ± 2.5) m / s, P <0.01]. In 807 people, there was a weak correlation between baPWV and left ventricular mass index (r = 0.19, P <0.01) without adjusting for other cardiovascular risk factors. However, after adjusting for age and systolic blood pressure, the association between the two was no longer significant (r = -0.008, P = 0.81). The relationship between baPWV and LVH was analyzed separately in men and women with similar results. The risk of LVH increased with the increase of baPWV in both men and women (OR = 1.30, P <0.01) or women (OR = 1.19, P <0.05) without adjusting for other cardiovascular risk factors (P < 0.05). However, after adjusting for age and systolic blood pressure, no correlation was found between men and women (P> 0.05). Conclusions The associations between baPWV and LVH, which reflect aortic and muscular atherosclerosis, are largely related to risk factors common to both forms of subclinical disease, such as age and systolic blood pressure.