Gap Junctional Intercellular Communication Increases Cytotoxicity and Reduces Resistance to Hydroxyu

来源 :癌症治疗(英文) | 被引量 : 0次 | 上传用户：sunj2009

【摘要】

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Background: Gap junctions enable small molecules to diffuse between adjacent cells and have been associated with greater cytotoxicity of radiation and anti-canc

【作者】

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Randall J. Ruch Paul D. Bouche

【机构】

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DepartmentofBiochemistryandCancerBiology,DepartmentofPharmacology,DrakeUniversityCollegeofPharmacyan

【出处】

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癌症治疗(英文)

【发表日期】

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2014年13期

【关键词】

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BYSTANDER Effect Drug RESISTANCE Gap JUNCTIONS HYDROXYUREA Ribonucleotide REDUCT

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Background: Gap junctions enable small molecules to diffuse between adjacent cells and have been associated with greater cytotoxicity of radiation and anti-cancer drugs. We investigated?whether this gap junctional intercellular communication (GJIC) affect

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Gap Junctional Intercellular Communication Increases Cytotoxicity and Reduces Resistance to Hydroxyu

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