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Objective To investigate wheat maxibastion of Guanyuan point on immune function and antitumor effect in mice with tumor.Method Group experiment and statistical analysis were conducted.Results were analyzed comparatively.Result Wheat maxibastion of Guanyuan point could reduce ATEP(associated tumor erythrocyte rate) and direct tumor erythrocyte rate(DTER) and raise excitotumorous erythrocyte rate(ETER)(P< 0.05,P< 0.01) and stimulate the reduced activity of NK cells and IL 2 significantly(P< 0.01) in mice with tumor.Conclusion Wheat maxibastion of Guanyuan point can increase the adhesion ability to tumor cells of RBC,and increase the activity of NK cell and IL 2.