论文部分内容阅读
人乳头瘤病毒中,第58型是很重要的高度致瘤性病毒之一。采用 Southern 印迹技术对我国14省区1216例宫颈癌及癌前病变组织进行人乳头状瘤病毒58型(HPV58)检测。结果:①各类宫颈组织中,宫颈癌组 HPV58型检出率(7.6%)最高;②南方地区宫颈癌组织中 HPV58型检出率(13.2%)高于北方地区(2.8%),表现出明显的地区差异;③与 HPV16型、18型检出率相比较,在宫颈癌组织中 HPV58型检出率低于 HPV16型,但明显高于 HPV18型。HPV58型与 HPV16型在各类宫颈疾患中的检出强度趋势大致相同。表明,HPV58型感染可能与我国特别是南方地区的宫颈癌病因有关。
Human papillomavirus type 58 is one of the most important highly tumorigenic viruses. Southern blotting was used to detect human papillomavirus type 58 (HPV58) in 1216 cases of cervical cancer and precancerous lesions in 14 provinces of China. Results: (1) In all kinds of cervical tissues, the HPV58 detection rate (7.6%) was the highest in cervical cancer patients; (2) HPV58 detection rate in cervical cancer tissues in southern area was higher than that in northern areas (2.8%) Obvious regional differences; ③ Compared with the detection rate of HPV16 and 18, the detection rate of HPV58 in cervical cancer was lower than that of HPV16, but significantly higher than that of HPV18. HPV58 type and HPV16 type in all kinds of cervical disease detection strength trend roughly the same. Show that HPV58 infection may be related to the cause of cervical cancer in our country, especially the South.