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皮下注射二巯基丁二酸钠1500毫克/千克,司将小鼠一次腹腔注射锑铵的半数致死量从90—112毫克/千克提高至1300—1460毫克/千克。静脈注身锑~(124)铵予家兔後,如立刻经同一途径注射二巯基丁二酸钠,亦可降低锑铵的急性毒性。二巯基丁二酸钠的解毒机制为阻止血锑进入组织,减少锑在部分组织中的含量及增加锑自尿排泄的速度。锑主要自尿排出,用二巯基丁二酸钠後,72小时内锑由尿排出给药量的96％,而对照组动物在同时间内仅有36％由尿排出。
Subcutaneous injection of sodium dimercaptosuccinate 1500 mg / kg, the Secretary once intraperitoneal injection of antimony ammonium in the median lethal dose increased from 90-112 mg / kg to 1300-1460 mg / kg. Intravenous antimony ~ (124) ammonium to rabbits, such as immediately by the same route of injection of sodium dimercaptosuccinate, ammonium antimony can also reduce the acute toxicity. Sodium dimercaptosuccinate detoxification mechanism to prevent blood antimony into the organization, to reduce the content of antimony in some tissues and increase antimony excretion rate. Antimony mainly excreted from the urine, with sodium dimercaptosuccinate, 72 hours after the discharge of antimony by urine 96%, while only 36% of the animals in the control group were excreted by urine.