血管钙化是动脉粥样硬化、糖尿病、肾病、衰老、收缩性高血压等多种疾病的病理生理基础 ,是心血管疾病的主要危险因子。最近研究发现血管钙化是一种类似于骨质疏松的主动的调节过程。然而 ,目前血管钙化的确切机制尚不清楚。可能与基质小泡、向钙性激素、钠依赖的磷酸转运系统、血管平滑肌细胞表型改变、周细胞、巨噬细胞和细胞凋亡等机制有关 Vascular calcification is the pathophysiological basis of a variety of diseases such as atherosclerosis, diabetes, nephropathy, aging, systolic hypertension and is a major risk factor for cardiovascular diseases. Recent studies have found that vascular calcification is an active regulator of osteoporosis. However, the exact mechanism of vascular calcification is not clear yet. May be related to matrix vesicles, to calcium hormones, sodium-dependent phosphate transport system, vascular smooth muscle cell phenotype changes, pericytes, macrophages and apoptosis mechanisms