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目的检测p53和c-myc蛋白在早期喉癌手术切缘组织中的表达及其与肿瘤局部复发的关系。方法选择2004—2010年间唐山市协和医院185例喉癌激光手术常规病理学检查手术切缘为阴性但术后肿瘤局部复发的24例为复发组,随诊2年无局部复发的161例为无复发组。免疫组化法检测2组手术切缘p53和c-myc蛋白。结果复发组手术切缘中p53蛋白阳性率为66.7%(16/24)明显高于无复发组18.6%(30/161)(P<0.05);复发组c-myc蛋白阳性率为83.3%(20/24),无复发组80.1%(129/161)。2组之间差异不显著(P>0.05)。结论喉癌手术切缘中p53蛋白阳性与术后局部复发明显相关,可预测喉癌术后局部复发高危患者及指导术后辅助治疗。
Objective To detect the expression of p53 and c-myc protein in the margins of surgical margins of early laryngeal squamous cell carcinoma and their relationship with the local recurrence. METHODS: Totally 185 patients with laryngeal cancer underwent routine laser biopsy at the Xiehe Hospital of Tangshan from 2004 to 2010 were retrospectively analyzed. Twenty-four patients with recurrent tumor after operation were negative, Recurrence group. Immunohistochemical method was used to detect the expression of p53 and c-myc in two groups. Results The positive rate of p53 protein in the surgical resection margin was 66.7% (16/24) in the recurrence group and 18.6% (30/161) in the non-recurrence group (P <0.05). The positive rate of c-myc protein in the recurrence group was 83.3% 20/24), and no relapse group 80.1% (129/161). There was no significant difference between the two groups (P> 0.05). Conclusion The positive p53 protein in the surgical margin of laryngeal carcinoma is obviously correlated with the local recurrence after operation. It can predict the high risk patients with local recurrence of laryngeal cancer and guide the postoperative adjuvant therapy.