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目的:研究氧化苦参碱(OMT)对大鼠急性心肌梗死诱发实验性心肌重塑的保护作用。方法:采用冠状动脉结扎术复制大鼠急性心肌梗死模型,随机分为模型组、OMT高剂量组、OMT中剂量组、OMT低剂量组、卡托普利组;假手术组只做冠状动脉穿线而不结扎。模型复制8周后分别测血流动力学指标以观察各组大鼠心功能的变化;计算心脏质量参数、心室重构参数,碱水解法测心肌羟脯氨酸含量以分析各组大鼠心肌重塑程度;并对心脏进行大体解剖学观察。结果:模型组大鼠血流动力学指标结果提示心功能显著恶化,心脏质量参数、心室重构参数、心肌羟脯氨酸含量及心脏大体解剖观察提示心肌重塑程度显著增加。与模型组比较,OMT具有改善心肌重塑大鼠心功能,抑制心肌重塑的作用。结论:OMT对急性心肌梗死诱发实验性心肌重塑具有一定的保护。
Objective: To study the protective effect of oxymatrine (OMT) on experimental myocardial remodeling induced by acute myocardial infarction in rats. METHODS: Rats with acute myocardial infarction were induced by coronary artery ligation and randomly divided into model group, OMT high dose group, OMT middle dose group, OMT low dose group, and captopril group; sham operation group was only used for coronary artery threading. Without ligation. After 8 weeks of model replication, hemodynamic parameters were measured to observe changes in cardiac function in each group; heart quality parameters, ventricular remodeling parameters were calculated, and alkali hydrolyzed method was used to measure myocardial hydroxyproline content to analyze myocardial myocardium in each group. Remodeling degree; general anatomy of the heart. RESULTS: The results of hemodynamic parameters in the model group indicated a significant deterioration of cardiac function. Cardiac quality parameters, ventricular remodeling parameters, myocardial hydroxyproline content, and gross anatomic observation of the heart suggested that myocardial remodeling significantly increased. Compared with the model group, OMT has the effect of improving myocardial remodeling in rats and inhibiting myocardial remodeling. Conclusion: OMT has certain protection on experimental myocardial remodeling induced by acute myocardial infarction.